Folinic acid is a bioactive form of folate that plays a crucial role in DNA synthesis and repair. It is often used in clinical settings to counteract the toxic effects of certain medications, especially in cancer treatments.
Unlike folic acid, folinic acid does not require activation by the body, making it a preferred option for those with genetic mutations that affect folate metabolism. It also supports brain health and reduces homocysteine levels.
Supplementation with folinic acid is often recommended for individuals with certain genetic conditions, such as MTHFR polymorphisms.
Synonyms: 5-Formyltetrahydrofolate, Leucovorin
Benefits:
- Supports DNA synthesis and repair
- Reduces homocysteine levels
- Enhances cognitive function
- Protects against medication side effects
Sources:
- Leafy greens
- Fortified foods
- Supplements
Notes:
- Often prescribed for medical conditions.
Reference: Folinic Acid in Genetic Disorders