Undenatured collagen refers to a form of collagen—typically type II—that is preserved in its native, biologically active structure, unlike hydrolyzed collagen which is broken down into peptides. It is derived mainly from chicken sternum cartilage and is used in very small doses compared to hydrolyzed forms.
This type of collagen is primarily used for joint health, where it helps modulate immune responses and reduce inflammation that can damage joint cartilage. In sports and fitness, it may help improve joint mobility and reduce discomfort associated with strenuous physical activity or overuse injuries.
Undenatured collagen works by interacting with the gut-associated lymphoid tissue (GALT), promoting oral tolerance and potentially slowing down joint tissue degeneration, particularly in active individuals or those with joint stress.
Synonyms:
Native Collagen Type II, UC-II® (branded form).
Benefits:
- Supports joint health and mobility
- Reduces exercise-related joint discomfort
- May help protect cartilage from degradation
- Supports long-term joint function in active individuals
Sources:
- Extracted from chicken sternum cartilage
- Preserved without high heat or enzymatic hydrolysis
Observations:
Typically used in very low doses (e.g., ~40 mg/day). Not intended as a protein source, but for joint-specific health. Should not be confused with hydrolyzed collagen peptides. Generally well tolerated, but excessive intake is unnecessary and not shown to provide additional benefits.
Areas of Study Related:
Orthopedics, Sports Medicine, Immunology, Nutritional Science.